Exploring the Association between Frequency Distribution of Secretor Status of ABH Antigenic Substances in Sickle Cell Traits and Sickle Cell Disease: A Systematic Review of Individual Data-based Meta-analysis of Published Literatures
Akpan, Idongesit Samuel
Department of Hematology and Blood Transfusion Sciences, Faculty of Basic Clinical Sciences, University of Uyo, Akwa Ibiom State, Nigeria.
Forwah Jacques Ndeh *
Department of Hematology and Blood Transfusion Sciences, Faculty of Clinical Sciences, University of Calabar, Cross River State, Nigeria.
Otti Chidiebere Joel
Department of Obstetrics and Gynaecology, University of Nigeria Teaching hospital Ituku -Ozalla, Enugu State, Nigeria.
Akaba Kingsley Onoride
Department of Hematology and Blood Transfusion Sciences, Faculty of Clinical Sciences, University of Calabar, Cross River State, Nigeria.
Edeani Bobby David
Department of Radiation Oncology, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Korzerzer Samuel Vershima
Department of Surgery, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Edim Okimedim Joseph
Department of Hematology and Immunology, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Okorie Ebubechukwu Obasi
Department of Radiation Medicine, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Emekwue Chukwudi Alex
Department of Internal Medicine, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Immaculate Ihuoma Ekeagba
International University of Bamenda, North West Region, Cameroon.
Okwu Prudence Chidera
Department of Internal Medicine, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Osahenrhunmwen Abraham Okunorobo
Department of Clinical Pharmacy Hallo Healthcare Limited Abuja, FCT, Nigeria.
Akam Nahaniel Ndim
Department of Hematology and blood transfusion National hospital Abuja FCT, Nigeria.
Ebot Walter Ojong
Department of Biomedical Science, Faculty of Health Sciences, University of Buea, South West Region, Cameroon.
Ezekoye Chisom Juliet
Department of Internal Medicine, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Onwuzu Chukwuka Arinze
Department of Surgery, University of Nigeria Teaching Hospital, Ituku -Ozalla, Enugu State, Nigeria.
Abeshi Sylvester Etenikang
Department of Obstetrics and Gynaecology, University of Calabar Teaching Hospital, Calabar Cross River State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: The association between the frequency distribution of secretor and non-secretor status of ABH antigenic substances among sickle cell traits and sickle cell disease are not well documented and understood by many in the research community and this may be due to paucity of knowledge on this subject.
Objective: The aim of the study is to systematically review and analyse all searched and extracted articles with citations from the individual data-bases/websites that have published literatures relating to the association between frequency distribution of secretor status of ABH antigenic substances among sickle cell traits and sickle cell disease population.
Methods: A comprehensive literature search was conducted using multiple data-based published literatures on various websites and data bases such as PubMed, Scopus, and Web of Science databases. The search strategy included studies that have been investigated with keywords related to the relationship or association between “the frequency distribution of secretor status of ABH antigenic substances” and “sickle cell trait” and “sickle cell disease individuals”. To achieve this a total of 250 studies were included in the review and 150 articles met the inclusion criteria and ten search engines were used for searching and extracting these articles.
Results: The result of the systematic review shows that frequency distribution of secretor and non-secretor status of ABH antigenic substances varied significantly with sickle cell trait and sickle cell disease as found in individual articles.
Conclusion: This systematic review suggests that there may be a significant relationship or association between the frequency distribution of secretion and non-secretor status of ABH antigenic substances and sickle cell traits and sickle cell disease state. Further studies may be needed to confirm these findings.
Keywords: Association, frequency distribution, secretor, non-secretor status, Abh antigenic substances, sickle cell traits, sickle cells disease