https://www.journalahrj.com/index.php/AHRJ <p style="text-align: justify;"><strong>Asian Hematology Research Journal</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AHRJ/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Hematology research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated.By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> <p>&nbsp;</p> Asian Hematology Research Journal en-US Asian Hematology Research Journal https://www.journalahrj.com/index.php/AHRJ/article/view/277 <p>Anaemia is a major global health challenge and is commonly associated with oxidative stress, haemolysis and metabolic disturbances, including dyslipidaemia. Phenylhydrazine (PHZ)-induced haemolytic anaemia is a widely used experimental model characterised by erythrocyte destruction and altered lipid metabolism. This study investigated the combined haematoprotective and hypolipidaemic effects of <em>Telfairia occidentalis</em> and <em>Carica papaya</em> leaf extracts in PHZ-induced anaemic Wistar rats. Twenty male albino Wistar rats were randomly assigned to four groups: normal control, PHZ-induced untreated group (negative control), PHZ-induced group treated with the standard drug (Oreifer®) and PHZ-induced group treated with combined ethanolic leaf extracts (200 mg/kg). Anaemia and dyslipidaemia were induced by intraperitoneal administration of PHZ (40 mg/kg) for four consecutive days, followed by seven days of treatment. Haematological parameters and serum lipid profile were assessed. The negative control group (Group B) exhibited marked haematological disruption, with increased WBC count (13.12 ± 2.1) and reduced RBC (2.9 ± 0.82), HGB (131.42 ± 7.0) and PCV (26.14 ± 5.5). This was accompanied by reduced HDL-C and increased LDL-C, TC and TAG levels, confirming the induction of anaemia and dyslipidaemia. Treatment with the combined extracts improved RBC, HGB and PCV, restoring values towards normal and producing effects comparable to the standard drug group. The extracts also significantly increased HDL-C and reduced LDL-C levels (p &lt; 0.05). However, reductions in TAG and TC were not statistically significant. WBC and platelet counts showed normalisation trends after treatment. Overall, the combined leaf extracts of <em>Telfairia occidentalis</em> and <em>Carica papaya</em> exhibited haematoprotective and selective hypolipidaemic effects in PHZ-induced anemia. These findings support their potential as complementary therapeutic agents in managing anemia and associated lipid abnormalities. Further studies are required to elucidate mechanisms, isolate active compounds, and establish safety for clinical use.</p> Osuvwe C. Ororoxro Israel O. Efejene Eromosele M. Aisuodionoe Oghenevwegba P. Ishokare Emmanuel O. Ogbotor Precious Ogbodu Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2026-09-01 2026-09-01 9 4 536 545 10.9734/ahrj/2026/v9i4277 https://www.journalahrj.com/index.php/AHRJ/article/view/278 <p><strong>Background:</strong> Splenic B-cell lymphoma/leukaemia with prominent nucleoli (SBLPN) is a rare chronic B-cell lymphoproliferative malignancy, comprising approximately 0.4% of all chronic lymphoid malignancies, with a reported annual incidence of 0.03 per million. Although prominent nucleoli with polar cytoplasmic projections are considered distinctive features of SBLPN, their assessment is often subjective and requires an experienced observer, which may lead to an imprecise diagnosis. Molecular studies are limited and inconclusive. Flow cytometry is often indispensable for the accurate characterisation of such atypical lymphoid cells.</p> <p><strong>Method:</strong> The study was an observational study of 10 cases diagnosed as SBLPN. The samples were processed using the stain-lyse-wash procedure and analysed using the BD FACSCANTO II analyser with BD FACS Diva software v9.0. A gating strategy using bright CD19 versus low side scatter was employed to analyse the lymphocyte population. A Matutes-based scoring system incorporating the HCL markers CD11c, CD103, CD123, and CD25 was used.</p> <p><strong>Result:</strong> SBLPN is a CD5-, CD10-, and CD25-negative B-cell lymphoproliferative disorder with positivity for CD11c and CD103. Of the 10 cases, eight had a score of 2 out of 4, while two had a score of 3 out of 4. None of the cases had a score of 0, 1, or 4.</p> <p><strong>Conclusion:</strong> SBLPN is a CD5-, CD10-, and CD25-negative B-cell lymphoproliferative disorder with positivity for CD11c and CD103. The Matutes immunophenotypic score using the four markers remains relevant and usually yields a lower score in SBLPN.</p> Abena Hidangmayum Beena Chandrasekhar Nagarjun Sai Jaine Kailash Singh Mehra Sunny Kumar Maurya Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2026-09-02 2026-09-02 9 4 546 552 10.9734/ahrj/2026/v9i4278