Evaluation of Common Coagulation Tests in Type 2 Diabetic Patients and Association with Diabetic Pre-cardiovascular Complications, Gezira State–Sudan, 2020-2021

Thu, 16 Sep 2021 00:00:00 +0000

Background and Objectives: Diabetes has an epidemic character because of the huge growth within side the wide variety of human affected in latest years. If laboratory findings display abnormalities connected to an improved threat of thrombosis, diabetes, specifically type 2, can present hypercoagulability symptoms. The aim of this study to evaluate the common coagulation parameters PT, aPTT, and D-dimer in patients suffering with diabetes type 2 and to associate these parameters with the thrombotic complication in those patients.

Methods: This was a case control study performed on 70 patients with diabetic type 2 from different ages (Their ages ranging from 20 -72 years with an average age of 56.2 years) and different gender (41.4% were males and 58.6% were females) attending the Diabetic Clinic of the Aldaraja Health Center, compared with 50 apparently healthy individual as a control group were enrolled in study and that in Wad Madeni, Gezira State, central of the Sudan in the period between June 2020 to January 2021, Blood were collected from each enrolled subject and the levels of PT, aPTT and D-dimer were measured.

Results: This study showed lower levels of PT and aPTT (patients 13.3 seconds/ control 14.3 seconds and patients 34.3 seconds/ control 36.6 seconds) respectively with highly significance difference (P. value = 0.001) respectively when compared with control group, while showed higher level of D-dimer (patients 585.3 ng/ml/ control 178.58 ng/ml) with highly significant difference (P. value = 0.000) when compared with control group. In diabetic patients without thrombosis (early onset of occurring thrombosis) had low level of PT with highly significant difference (P. value = 0.000) when compared with diabetes plus thrombosis and control groups.

Conclusion: We concluded that the Sudanese diabetic patients had a procoagulant state that would result in thrombosis, so we advocated that diabetic patients, specifically type 2 to take delivery of anticoagulant therapy for as a minimum a quick time as a preventative degree to keep away from thrombus formation, specifically cardiovascular.

Spectrum of Complications in Patients of Acute Leukemia- A Regional Study from Pgims, Rohtak

Sudhir Kumar Atri, . Homdutt, Devender Yadav, Bhanu Pratap Singh, Shiv Kumar — Thu, 07 Oct 2021 00:00:00 +0000

Objectives: This study was conducted to determine the spectrum of complications in patients of acute leukemia.

Materials and Methods: The present study was conducted at Pandit Bhagwat Dayal Sharma Post

Graduate Institute of Medical Sciences, Rohtak and data was collected from patients who presented with confirmed diagnosis of acute leukemia over a period of one year. Patients satisfying inclusion criteria were monitored for development of any complications. Baseline parameters were recorded on admission and then every 7 days interval till remission. Data were analyzed by statistical package for social sciences (SPSS) version16.0.

Results: The data was collected from 35 patients. Most common presenting complaint was fever in 88.6% of patients. AML was diagnosed in 16 patients (45.7%) and rest had ALL (54.2%). In our study about 25% of patients had bleeding symptoms at presentations and almost 100% of patients developed bleeding complications during induction therapy. Most common sites of bleeding in our study was cutaneous bleed (100%) followed by gum bleed (26.4%). Life threatening bleeding in form of intracranial bleed was noted in 4 patients of which 3 patients died of bleeding complications amounting to 27.2%. Among 34 patients twenty two patients (64.7%) had neutropenia. Infectious complications were the second most common complication noted in our study. Most common infectious complication was pneumonia seen in 25.9% of febrile patients followed by blood stream infection (18.5%). An infectious etiology was documented in 33.3% of patients with frequency of gram negative and gram positive infections was 88.9% and 11.1% respectively. Pseudomonas sp was the most commonly (44.4%) isolated micro-organism. Among patients with pneumonia fungal etiology was identified in 71.4% of patients making IFIs one of the most frequent infectious complications in acute leukemia patients. In our study 18.7 % of patients developed TLS, all patients had Laboratory TLS and only one patient had Clinical TLS. One patient developed L-asparaginase induced acute pancreatitis and one patient developed differentiation syndrome.

Conclusion: Acute leukemia is a devastating disease with wide spectrum of complications not only related to disease part but also because of its treatment

Asian Hematology Research Journal

Evaluation of Common Coagulation Tests in Type 2 Diabetic Patients and Association with Diabetic Pre-cardiovascular Complications, Gezira State–Sudan, 2020-2021

Spectrum of Complications in Patients of Acute Leukemia- A Regional Study from Pgims, Rohtak